Adaptive Design Methods in Clinical Trials, Second Edition (Chapman & Hall/CRC Biostatistics Series)

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Bayesian Designs for Phase Iâ II Clinical Trials Chapman & Hall CRC Biostatistics Series

For anyone working in, and studying, clinical research the book is worth purchasing and will make a valuable addition to any library. Praise for the First Edition The authors are to be commended for the endeavour to provide a monograph about this rapidly evolving area in- to our knowledge- the first book specifically devoted to adaptive design methods.

In summary, this is an extremely useful book for clinical trials statisticians wishing to stay abreast with the innovative approaches that are being developed amid some controversies regarding their benefits. This breadth of coverage is to be commended and makes the book a useful reference and overview for anyone who is starting to explore this area … the book is worth reading.

The book covers a vast area. To my knowledge this book is the first attempt to provide a concise description of various methodologies in a highly dynamic area. The authors deserve to be praised for bringing this huge range of approaches, including very recent trends, together in one book …. We provide complimentary e-inspection copies of primary textbooks to instructors considering our books for course adoption.


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Adaptive Design Methods in Clinical Trials

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Summary With new statistical and scientific issues arising in adaptive clinical trial design, including the U. Author s Bio Author. Reviews "Those familiar with the first edition will find substantial updates as well as five entirely new chapters … The scope is wide-ranging …" — ISCB News , 59, June "In this second edition, the authors update two chapters on protocol amendment and clinical trial simulation to reflect new developments after the first edition and add five new chapters.

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It is certainly a useful guide and reference for academic and industry statisticians alike. We provide complimentary e-inspection copies of primary textbooks to instructors considering our books for course adoption. Most VitalSource eBooks are available in a reflowable EPUB format which allows you to resize text to suit you and enables other accessibility features. Where the content of the eBook requires a specific layout, or contains maths or other special characters, the eBook will be available in PDF PBK format, which cannot be reflowed. For both formats the functionality available will depend on how you access the ebook via Bookshelf Online in your browser or via the Bookshelf app on your PC or mobile device.

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Adaptive Design Theory and Implementation Using SAS and R - CRC Press Book

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Description Table of Contents Reviews. Summary Get Up to Speed on Many Types of Adaptive Designs Since the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. New to the Second Edition Twelve new chapters covering blinded and semi-blinded sample size reestimation design, pick-the-winners design, biomarker-informed adaptive design, Bayesian designs, adaptive multiregional trial design, SAS and R for group sequential design, and much more More analytical methods for K-stage adaptive designs, multiple-endpoint adaptive design, survival modeling, and adaptive treatment switching New material on sequential parallel designs with rerandomization and the skeleton approach in adaptive dose-escalation trials Twenty new SAS macros and R functions Enhanced end-of-chapter problems that give readers hands-on practice addressing issues encountered in designing real-life adaptive trials Covering even more adaptive designs, this book provides biostatisticians, clinical scientists, and regulatory reviewers with up-to-date details on this innovative area in pharmaceutical research and development.

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